Mechanism of Action :
Maxacalcitol inhibits the PTH secretion effect on parathyroid cells in normal cattle and in parathyroid cells in people with chronic renal atrophy (in vitro), and this inhibitory effect is similar to that of calcitriol.
A model study of renal failure in animals (rats with five-sixth kidney removed and dogs with ligation of renal artery) showed that maxacalcitol inhibits PTH secretion at a dose that does not increase serum calcium concentration.
Indication :
Maxacalcitol is indicated for secondary hyperparathyroidism of the patients receiving maintenance dialysis.