Mechanism of Action :
Taltirelin is a derivative of thyrotropin-releasing hormone (TRH). It would bind to TRH receptors which are widely distributed in the central nervous system, and improve ataxia in spinocerebellar degeneration by activating acetylcholine, dopamine, noradrenaline, and serotonin nervous systems. In addition, spinal reflex enhancing action, neurotrophic factor-like action, and local glucose metabolism promoting action are also considered to be involved in drug efficacy.
Indication :
Taltirelin is indicated for the improvement of ataxia in spinocerebellar degeneration.