Mechanism of Action :
Sevelamer Hydrochloride is a non-absorbed binding crosslinked polymer. It contains multiple amines separated by one carbon from the polymer backbone. These amines exist in a protonated form in the intestine and interact with phosphate molecules through ionic and hydrogen bonding. By binding phosphate in the dietary tract and decreasing absorption, sevelamer hydrochloride lowers the phosphate concentration in the serum.
Indication :
Sevelamer Hydrochloride is a phosphate binder indicated for the control of serum phosphorus in patients with chronic kidney disease on dialysis.